Developments of research on Alzheimer's Essay Example | Topics and Well Written Essays - 1000 words

Developments of research on Alzheimers - Essay ExampleThe relationship of neuropathological features of Alzheimers Disease to the topic of cognitive deficits, is not fully understood currently. However, the process that results in the accumulation of A as mealy triggers the complex pathological changes ultimately leading to cognitive impairments (Sun, 2007, p.40), known as the amyloid cascade hypothesis. Lichtien and Mohajeri (2008) offer that the high morbidity, socioeconomic costs, and lack of specific treatments indicate the importance of research on Alzheimers Disease. testify from Lichtien and Mohajeris (2008) research on the efficacy of anti-amyloid immunization strategies, indicates that they serve as effective protective mechanisms against Alzheimers Disease. However, the underlying mechanisms of action of therapeutic antibodies, particularly their impact on the complex amyloid peptide (A) metabolism and various(a) A equilibria present both on the internal and external s ides of the central nervous system, are not fully clear as yet. Moreover, physiological A metabolism is not fully understood because of piteous analytical tools to characterize and quantify treatment effects. Further, biomedical research is aimed at developing predictable therapies minimizing the essay of adverse effects such as brain inflammation and/ or hemorrhage caused by anti- A immunization protocols.The researchers found that standard Enzyme Linked Immune Sorbant Assay (ELISA) protocols are inadequate in perspicacious drug design, and there is a requirement for more complex analytical tools to be developed and applied. Tests ensuring greater reliability in the assessments of A in free versus protein-bound form, as well as monomeric versus aggregated A, will be key to identifying the mechanisms forming the basis for efficacy and safety of the